The sequester will set back medical research for a generation.

According to the former director of the NIH, Dr. Elias Zerhouni (in the Washington Post):

The NIH is facing an 8.2 percent across-the-board cut in future years (5.3 percent for 2013).

The most impacted are the young, new investigator scientists, who are coming into science, and will now abandon the field of science. There will be a generational gap created.